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Pharmaceutical Manufacturer – Ireland

Pharmaceutical

Drying Contaminated Syltherm 800 Within Seven Days to Save a High-Value Batch

System Type

Syltherm 800 thermal fluid system (20,000 litres)

The Challenge

Following a cooling water heat exchanger failure, a high-value product batch (still in patent) was left incomplete mid-process.

The thermal fluid contained free water and unknown contamination levels.

Initial laboratory testing confirmed 2,560 ppm water content.

Target requirements:

  • Reduce water content to <50 ppm
  • Maintain processing temperature of -22°C
  • Complete within 7 days

The Solution

TFS were consulted on Day 1 (Friday). Samples were analysed immediately.

By Day 3, a thermal fluid heater, booster pumps and flash evaporator were delivered to site in Ireland.

Installation and commissioning were completed on Day 4 (Monday).

Drying was completed within 42 hours.

  • Water removed: 68 litres
  • Final water content: 36 ppm

Production recommenced at 8am on Day 7 (Thursday).

The Result

  • Batch saved
  • Water reduced from 2,560 ppm to 36 ppm
  • Total turnaround achieved within 7 days
  • Production resumed on schedule

We didn’t think it was possible. When we first saw the free water pouring off the condenser we finally believed we could do it! – Thanks…

Production Manager

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